Browsing by Author "Salvadori, S."

Now showing items 1-3 of 3

    • Article  

      Characterization of the bifunctional opioid UFP505 

      Tose, R.; Dietis, Nikolas; McDonald, J.; Guerrini, R.; Calo, G.; Salvadori, S.; Rowbotham, D. J.; Lambert, D. G. (2010)
      Morphine is a gold standard analgesic acting at μ-opioid receptors (MOP) with analgesia accompanied by side-effects, for example, tolerance. If δ-opioid receptors (DOP) are blocked at the same time that MOP is activated, ...
    • Article  

      In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP-505 

      Dietis, Nikolas; Niwa, H.; Tose, R.; McDonald, J.; Ruggieri, V.; Filaferro, M.; Vitale, G.; Micheli, L.; Ghelardini, C.; Salvadori, S.; Calo, G.; Guerrini, R.; Rowbotham, D. J.; Lambert, D. G. (2018)
      Background and Purpose Targeting more than one opioid receptor type simultaneously may have analgesic advantages in reducing side-effects. We have evaluated the mixed μ opioid receptor agonist/ δ opioid receptor antagonist ...
    • Article  

      Simultaneous targeting of multiple opioid receptors: A strategy to improve side-effect profile 

      Dietis, Nikolas; Guerrini, R.; Calo, G.; Salvadori, S.; Rowbotham, D. J.; Lambert, D. G. (2009)
      Opioid receptors are currently classified as (mu: mOP), δ (delta: dOP), κ (kappa: kOP) with a fourth related non-classical opioid receptor for nociceptin/orphainin FQ, NOP. Morphine is the current gold standard analgesic ...